Huntington disease (HD) is a fatal neurodegenerative movement disorder caused by an expanded CAG repeat in the huntingtin gene (HTT).The mutant huntingtin protein is ubiquitously expressed, but only certain brain regions are affected.The hypothalamus has emerged as an important area of pathology with selective loss of neurons expressing the neurope
Abstract 3-hydroxyisobutyryl-CoA hydrolase deficiency (HIBCHD) is a rare metabolic disease.Early symptoms include poor feeding, seizures, hypotonia and impaired psychomotor development.Acute metabolic crisis can cause encephalopathy with high risk of neurological sequelae or death.Casuistic, we here report a nine-year old Danish girl with HIBCHD Ni
Background: Obstructive sleep apnea syndrome (OSAS) in children is indeed a significant and often underdiagnosed condition.The risk factors for OSAS vary across different stages of life.Objectives: Identifying risk factors early can help in taking preventive measures to reduce the likelihood of developing OSAS, and different life stages may require
Abstract Background Staphylococcus aureus is an important pathogen causing a wide range of infections in the hospital and community setting.In order to have adequate information for treatment of S.aureus infections, it is crucial to understand the trends in the antibiotic-resistance patterns.In addition, the occurrence and changes in types of S.aur
This work presents one and two-dimensional numerical analyses using isotropic and anisotropic damage models for the concrete in order to discuss the advantages of these modeling.Initially, it is shortly described the damage model proposed by Mazars.This constitutive model assumes the Nike Air Max Terrascape Plus concrete as isotropic and elastic ma